F. tigrina, the Tiger Cat (Little Spotted Cat/Oncilla) can interbreed although most offspring are stillborn and meetings between Tiger Cats and domestic cats normally resulted in the death of the domestic due to the Tiger Cat's highly aggressive nature. Paul Leyhausen reported successful matings between a male Oncilla and a female domestic cat. Out of seven kittens born, three were stillborn. However, the Oncilla male was notably aggressive towards female Oncillas and it also killed a domestic female much larger than itself. These hybrids resulted from an Oncilla that accidentally and successfully bred with Abyssinian cats owned by Dutch cat specialist Mme Falken-Rohrle (aka Maria Falkena) of Arnhem. Mme Falken Rohrle was attempting to cross Oncillas with Margays. She had raised the Oncillas alongside domestic Abyssinians in order to make them better housepets. Completely by chance, a small cross-breed kitten was born as the result of an Oncilla x Abyssinian mating. Mme Falken-Rohrle was intrigued as to whether the kitten, named "Gloria" was a hybrid or a mutation of the Abyssinian so she deliberately bred an Abyssinian male to an Oncilla female. Three more cross-breed kittens were born and apparently thrived. This was apparently in the 1950s or 1960s and nothing has been heard of the hybrids since.

The Oncilla-Abyssinian hybrids were described by Leyhausen and Falkena as "very beautiful". Their coats had three longitudinal stripes down the back and the rest was patterned with small spots partly arranged into rosettes. The tails were ringed with a number of black hoops. The tail-tip was black. Since the oncilla has 36 chromosomes compared to the 38 of domestic cats, the F1 males would have been sterile though the females would probably have been fertile (a comparable case is the Safari breed developed from Geoffroy's Cats and domestic cats).

Leyhausen, P and Falkena M (1966) Breeding the Brazilian ocelot-cat (Leopardus tigrinus) in captivity. International Zoo Yearbook Vol 6; 176-182